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American Society of Microbiology ABMM Sample Questions:

1. A neonate develops a vesicular rash, fever, and seizures within the first week of life. CSF analysis reveals lymphocytic pleocytosis and elevated protein. PCR of the CSF is positive for a double-stranded DNA virus.
The MOST likely causative agent is:

A) Herpes simplex virus (HSV)
B) Human parvovirus B19
C) Varicella-zoster virus (VZV)
D) Cytomegalovirus (CMV)

2. A research laboratory is studying the pathogenesis of respiratory syncytial virus (RSV) infection in infants.
They find that a specific viral surface glycoprotein is primarily responsible for attachment to host cells. This glycoprotein is:

A) Hemagglutinin (H)
B) Neuraminidase (N)
C) Matrix protein (M)
D) Fusion protein (F)

3. A patient with a history of valvular heart disease undergoes a dental procedure and subsequently develops a bloodstream infection with Streptococcus mutans. This organism gains access to the bloodstream primarily due to:

A) Active invasion of the oral mucosa.
B) Production of potent extracellular enzymes.
C) Transient bacteremia resulting from the procedure.
D) Formation of a protective biofilm on the teeth.

4. A clinical trial is evaluating the efficacy of a new antifungal agent against invasive aspergillosis. Serum galactomannan levels are being used as a biomarker to monitor the infection. A decrease in galactomannan levels during treatment would indicate:

A) Concurrent infection with a non-Aspergillus mold.
B) Successful clearance or reduction of the Aspergillus burden.
C) Development of resistance to the antifungal agent.
D) A false-positive result in the galactomannan assay.

5. A patient with a history of neutropenia following chemotherapy develops a rapidly progressive pneumonia.
Bronchoalveolar lavage fluid reveals septate hyphae with acute angle (45-degree) branching. The MOST likely diagnosis is invasive pulmonary aspergillosis caused by:

A) Fusarium species
B) Aspergillus fumigatus
C) Rhizopus species
D) Mucor species

Solutions: